Mutation of the p53 gene is the most common genetic alteration yet revealed in human cancers which brings about unrestrained cellular proliferation.
In cervical cancers, p53 inactivation with human papilloma virus oncoprotein occurs in the majority of the cases. Mutant P53 proteins have a prolonged half-life, accumulated in the nucleus and can be detected by immunohistochemistry. Despite wide
range
of discrepancies due to differences in the methodologies employed, it is now well accepted that there is generally a concordance between p53 gene mutation and immunohistochemistry.
There has been a few reports on p53 overexpression in cervical cancers, however, few have addressed its relationship with prognostic factors. We have intended to observe the correlation between p53 overexpression and several clinical prognostic
factors
of cervical cancer, and the conclusion are,
1. 0% of p53 overexpression had been detected at the normal cervical tissue and tissue of CIN I-II, 9.5%(2/21) in the case of CIN III, 33.9%(32/102) in the case of invasive cervical cancer.
2. We had not been able to lead to any direct statistical significance from the correlation between the p53 overexpression and the clinical prognostic factors of cervical cancer, However, since under the situations of higher stage of cancer,
bigger
size of the tumor(size of smaller than 3 cm to bigger than 3 cm is 28.6% to 45.7%), and with the invasion of lymph node(state with invasion to without invasion is 30.9% to 50%), a lot higher percentage of p53 overexpression rate is observed, it
can
be
conjectured that p53 overexpression rate, which affects on the late stage tumorigenesis of cancer in this study, could be a important prognostic factor,
So, if the studies are continued with long-term follow up observation to more cases of being progressed more than the third stage, we may be able to expect effective conclusion from this study.
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